Influence of parenteral injection of trehalose on mammals with different trehalase levels

: Administration of trehalose by parenteral route to mammals (Guinea-pig and rabbit) equipped with Kidney trehalase is followed by rapid hydrolysis of the disaccharide which is excreted in urine only in very low amounts. When the animal under investigation has not trehalase in the kidney (rat), practically the total amount of trehalase is excreted in urine. Perfusion of kidney in rabbit confirms the very rapid hydrolysis of trehalose by this organ.