The Role of Biogenic Amines in the Progression of Cerebral Ischemia and Edema: Modification by p-Chlorophenylalanine, Methysergide, and Pentoxyfilline

Disorders of monoamine neurotransmitter metabolism, particularly 5-hydroxytryptamine and dopamine, may play some part in the early development of edema and in the progression of ischemia. This early edema seems potentially reversible if ischemia is relieved but continued ischemia leads to profound depletion of monoamine neurotransmitters and cyclic AMP in brain, coupled with progressive edema.