Les facteurs de risques d'acquisition d'une blastomycose endémique

BACKGROUND: Blastomycosis is potentially fatal, but environmen- tal risk factors for acquiring blastomycosis are not well established. METHOD: Matched cross-sectional questionnaire of 112 patients with history of blastomycosis and 118 control subjects in Manitoba and northwestern Ontario. RESULTS: The most common tissues involved with blastomycosis were pulmonary, skin and soft tissues, and bone. A significantly greater proportion of patients with blastomycosis than control subjects were involved in outdoor occupations. A significantly greater percentage of patients with blastomycosis were immunosuppressed either from col- lagen vascular disease or immunosuppressive therapy, or had hypothy- roidism. A significant association between canine and human blastomycosis was not observed. CONCLUSIONS: Independent risk factors for development of blasto- mycosis included immunosuppression for any reason (including drugs or disease), collagen vascular disease, being an outdoor worker, and having a coworker with blastomycosis. Canine blastomycosis was not a risk factor for human disease in dog owners.