Characteristics and Mortality of Hospitalized Patients With COVID-19 in Iran: A National Retrospective Cohort Study.

Background: Coronavirus disease 2019 (COVID-19) is a serious health care concern in Iran, with 259 652 confirmed cases since the first report on 18 February 2020, and Iran has the ninth highest national death toll in the world, with more than 13 000 deaths (1) Despite the immensity of the problem, there are limited data available about the characteristics and mortality of hospitalized patients in Iran Objective: To assess the characteristics and mortality of hospitalized patients with COVID-19 in Iran Methods and Findings: The Medical Care Monitoring Center of the Ministry of Health and Medical Education (MOHME) of Iran mandated all hospitals to register patients admitted with a diagnosis of confirmed or suspected COVID-19 in a national registry The registry included patient demographic characteristics, coexisting diseases, and presenting signs and symptoms Fever and hypoxemia were evaluated by the health care provider, and other variables were reported by the patient The Information Technology Center of MOHME provided access to this database In this retrospective cohort study, we enrolled all consecutively hospitalized adults and children with laboratory-confirmed COVID-19 who were admitted to any of the 1034 hospitals in Iran from 20 February to 20 April 2020 We defined laboratory confirmation as at least 1 positive result on real-time reverse transcriptase polymerase chain reaction assay of a specimen collected on a nasopharyngeal swab according to World Health Organization protocols Patients who had a negative or pending test result at the cutoff of the study period were excluded Pregnant patients were also excluded The institutional review board of Tehran University of Medical Sciences approved the study protocol The requirement for informed consent was waived because this study was regarded as minimal-risk research using data collected for routine clinical practice Furthermore, researchers analyzed only deidentified data We used the Kaplan-Meier method to estimate the probability of death (final event) from the date of hospital entry (starting event) Patients who had been discharged were assumed to be alive at the end of the study period;those who had been discharged or were still hospitalized at the study closeout were censored, and the last day of the study period was used to compute the time at risk Among 62 955 patients admitted to the designated hospitals during the study period, 29 111 tested positive for severe acute respiratory syndrome coronavirus 2 A total of 130 were excluded because of pregnancy, leaving 28 981 patients in the study population At study closeout, 23 367 patients had either been discharged or died Patients' demographic and clinical characteristics are shown in Table 1 Overall, 23 367 patients had a definitive outcome during the study period When all patients admitted during the study period were used in the Kaplan-Meier analysis of survival, the cumulative risk for in-hospital mortality in 30 days was 24 4% Table 2 presents the 30-day risk for death in different patient groups Discussion: We describe the characteristics and mortality among hospitalized patients with laboratory-confirmed COVID-19 in Iran The high case-fatality rate we saw is consistent with the hospitalized population;milder cases were likely excluded Consistent with other studies, hypoxemia, fever, and cough were common presenting symptoms, as were comorbidities (2-5) Although this was a large nationwide study that evaluated patients with laboratory-confirmed COVID-19, it has several notable limitations The study population is from 1 country Criteria for hospitalization may vary among countries, and this may make it difficult to compare mortality rates Most of the patient variables were self-reported and could not be verified Although guidelines on how to record data in the database were provided, no assessment of interrater reliability was done, and reporting among hospitals may have varied Moreover, this national database lacks detailed clinical information Our database included o