The effect of chlorhexidine on the receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG) expression in chronic periodontitis in humans and companion animals
2010
% OPG % RANKL
KR nema
AB Periodontal disease is a chronic, multi-factorial disease of the tissues
supporting the teeth. Periodontitis in companion animals is an almost
identical disease to that in humans in terms of disease course and clinical
presentation. Receptor activator of NF-kB ligand (RANKL) and osteoprotegerin
(OPG) are bioactive molecules that control bone resorption. This study aims
to evaluate the effect of Chlorhexidine (CXD) on the RANKL and OPG
expressions in gingival crevicular fluid (GCF) collected from subjects with
chronic periodontitis. GCF was obtained from subjects with chronic
periodontitis.10 subjects (CXD1) rinsed the mouth with 0.12% CXD, 10
subjects (CXD2) utilized 0.20% CXD and the last 10 (PL) used Placebo
solution for 7 days. RANKL and OPG concentrations in GCF were measured by
enzyme-linked immunosorbent assays ELIat baseline and after 7 days.
Periodontal clinical variables: clinical attachment loss (CAL), probing
pocket depth (PPD), papilla-bleeding index (PBI) were evaluated in all
groups. After 7 days in CXD1 and CXD2 group RANKL/OPG ratio exhibited a
significant decrease (p<0.05) in contrast to the PL group where results
showed similar values of RANKL/OPG ratio at baseline and after the
observation period. RANKL/OPG ratio was positively correlated with PPD, CAL
and PBI before and after the observation period in both Chlorhexidine (CXD1,
CXD2) groups. In an existing inflammatory response, chlorhexidine reduced
the level of periodontal inflammation, which leads to reduction of RANKL/OPG
relative ratio. Decrease of RANKL/OPG ratio will apparently induce
maintenance of alveolar bone and slow down periodontal tissue breakdown.
Parodontopatije su hronicna, multikauzalna oboljenja potpornog aparata zuba.
Parodontalna oboljenja koja srecemo kod kucnih ljubimaca su prema toku i
klinickoj slici skoro identicna onima koje se javljaju kod ljudi. RANKL i
osteoprotegerin (OPG) su bioaktivni molekuli koji kontrolisu kostanu
resorpciju. Cilj ove studije je evaluacija efekata hlorheksidina na
ekspresiju RANKL-a i OPG-a u gingivalnoj tecnosti (GT) uzetoj od pacijenata
sa hronicnom parodontopatijom. 10 pacijenata (CXD1) su ispirali usta sa
0.12% CXD, 10 pacijenata (CXD2) su koristili 0.20% CXD i poslednjih 10
pacijenata (PL) su koristili placebo rastvor 7 dana. RANKL i OPG
koncentracije u GT su merene ELItestom na pocetku i posle sedam dana.
Parodontalni klinicki parametri CAL, PPD i PBI su evaluirani u svim grupama.
Posle 7 dana u CXD1 i CXD2 grupi RANKL/OPG odnos je pokazao signifikantno
smanjenje (p<0.05) u poređenju sa PL grupom gde su zabaleženi slicni
rezultati na pocetku i nakon opservacionog perioda. RANKL/OPG odnos je
pokazao pozitivnu korelaciju sa vrednostima PPD-a, CAL-a i PBI-a pre i nakon
observacionog perioda u obe eksperimentalne grupe (CXD1, CXD2). U prisutnom
inflamatornom odgovoru hlorheksidin je redukovao nivo inflamacije, sto je
uslovilo redukciju RANKL/OPG odnosa. Rezultati istraživanja dokazuju da
koncentracija hlorheksidina ne utice statisticki znacajno na smanjenje
RANKL/OPG odnosa.
PR Projekat Ministarstva nauke Republike Srbije, br. P145042
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