Synthesis and Antibacterial Activity of 1β‐Methyl‐2‐(5‐substituted thiazolidinopyrrolidin‐3‐ylthio)carbapenems and Related Compounds.

The synthesis of a new series of 1beta-methylcarbapenems containing the substituted thiazolidinopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the thiazolidine ring was investigated.A particular compound (18 c) having a 2-amide substituted thiazolidine moiety showed the most potent antibacterial activity.