Novel potential inhibitor discovery against tyrosyl-tRNA synthetase from Staphylococcus aureus by virtual screening, molecular dynamics, MMPBSA and QMMM simulations

Chiako Farshadfar,Adriano Mollica,Fatemeh Rafii,Akbar Noorbakhsh,Mozhgan Nikzad,Seyed Hamid Seyedi,Fatemeh Abdi,Somayeh Abbasi Verki,Sako Mirzaie

Novel potential inhibitor discovery against tyrosyl-tRNA synthetase from Staphylococcus aureus by virtual screening, molecular dynamics, MMPBSA and QMMM simulations

2020

Chiako Farshadfar
Adriano Mollica
Fatemeh Rafii
Akbar Noorbakhsh
Mozhgan Nikzad
Seyed Hamid Seyedi
Fatemeh Abdi
Somayeh Abbasi Verki
Sako Mirzaie

The abuse and overuse of antibiotics is the main responsible for the raising antibiotic resistance among bacteria and as a consequence the of diseases severity and treatment complications. Staphylo...

Keywords:

Molecular dynamics
Tyrosyl-tRNA Synthetase
Chemistry
Virtual screening
Computational chemistry
Biochemistry
Staphylococcus aureus
Microbiology
Antibiotics
Bacteria
Treatment complications
Antibiotic resistance

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