[Studies on bioactive constituents from the excreta of Trogopterus xanthipes Milne-Edwards]
1987
Thirteen constituents were isolated from the excreta of Trogopterus xanthipes Milne-Edwards, and nine of them were identified as pyrocatechol(Ⅰ), benzoic acid(Ⅱ), 3-caren-9,10-dicarboxylic acid(Ⅲ), uracil(Ⅳ), m-hydroxy benzoic acid(Ⅵ), protocatechuic acid(Ⅶ), hypoxanthine(Ⅺ), allantion(Ⅻ), L-tyrosine(ⅩⅢ). All of them were first reported to occur in the excreta of Trogopterus xanthipes Milne-Edwards. A new compound, wulingzhic acid(Ⅴ) was elucidated on the basis of spectral data (IR, MS, ~1H-NMR, ~(13)C-NMR). Pharmacological experiments showed that compounds(Ⅰ)~(Ⅶ) inhibited markedly the aggregation of platelet in vitro, and (Ⅰ), (Ⅲ), (Ⅴ), (Ⅶ) have antibacterial activities to different dgerees. Structure determination of the other compounds is still underway.
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