体外评价29种中药的抗结核分枝杆菌活性 In Vitro Evaluation of the Potential Anti Mycoba-Cterium Tuberculosis Activity of 29 Chinese Traditional Medicinal Plants

结核病是迄今为止最难控制的传染病之一，且近年来呈上升趋势。中药是新药发现的重要来源之一，且在我国储存量大。本试验选取29种中草药，分别对结核分枝杆菌H37Rv和牛分枝杆菌BCG菌株进行活性筛选，发现14种中草药具有抗结核杆菌作用，其中9种中草药与异烟肼和利福平存在协同抗菌作用，首次发现三角条具有抗结核杆菌活性。研究结果为发现新型抗结核杆菌分子骨架奠定了基础。 Tuberculosis is one of common infectious diseases that has been difficult to control so far and has been on the rise in recent years. Chinese herbal medicine is an important natural resource for the discovery of new drug, and China has a wealth of natural medicine resources. In this experiment, 29 traditional Chinese medicines were selected for the screening of anti-M tuberculosis H37Rv and BCG respectively. The results indicated that 14 kinds of herbs showed powerful activity against Myco-bacterium tuberculosis H37Rv and BCG. Among them, 9 kinds of Chinese herbal medicine exhibited synergistic antibacterial effect combined with isoniazid and rifampicin respectively. In addition, it was first discovered that the Sanjiaotiao (Chinese name) had anti-Myco bacterium tuberculosis activity. The study laid the foundation for the discovery of the new skeleton of anti-Mycobacterium tuberculosis drug.