Menopause and hormone therapy in the 21st century: why promote transdermal estradiol and progesterone?

To the Editor: In their editorial,1 Gersh and Lavie describe the many ways that estradiol impacts cardiovascular health. In addition, the authors rightly question the findings of the Women’s Health Initiative among menopausal women using hormone therapy. Importantly, they emphasise the need for using the most physiological human-identical transdermal estradiol combined with natural progesterone. However, no information is given on …