Ketonic Mannich Bases and the Products of their Reduction and Bromination

A group of ketonic bases, indicated as types I and II, were synthesized by means of the Mannich reaction for pharmacological study. Certain of the type I Mannich bases were then reduced by means of aluminum isopropoxide to nitrophenyl amino alcohols (type III) for use as side chains in future studies. Other type I bases were brominated to give ketonic nitrogen mustards for study against cancer. Except for appreciable in vitro antituberculous activity of some of the Mannich bases, there were no noteworthy pharmacological results.