The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.
2013
Antibody responses are impaired during HIV-1 infection. Cicala and colleagues show that the HIV-1 glycoprotein gp120 directly impairs B cell function by promoting expression of TGF-β and the inhibitory receptor FcRL4.
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