Carboxymethyl high amylose starch for F4 fimbriae gastro-resistant oral formulation
2007
Calinescu C, Nadeau E, Mulhbacher J, Fairbrother JM, Mateescu MA. The carboxymethyl high amylose starch (CM-HAS) was proposed as excipient able to protect F4 fimbriae oral vaccine against gastric acidity and pepsin, allowing its subsequent liberation in the intestinal fluid. Thus, F4 fimbriae formulated with CM-HAS as tablets displayed a markedly higher stability after 2h of incubation in simulated gastric fluid (containing pepsin) than the free, non-protected F4 fimbriae, which, in these (...)
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