Abnormal Hedgehog pathway in myelodysplastic syndrome and its impact on patients’ outcome

Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and by cytopenias. Approximately 30% of patients with MDS progress to acute myeloid leukemia.[1][1] Thus, it is important to identify risk factors for AML progression and to guide