Febuxostat preparing a crystalline form of

2011 
The invention belongs to the field of medicine chemistry and particularly relates to a method for preparing Febuxostat crystal A. The method comprises: dissolving, crystallizing and drying, wherein the dissolving is to dissolve Febuxostat in a solvent with heating in a water bath, the solvent may be RCOCH3 or RCH2OH, R may be methyl or ethyl, the mass/volume ratio of the Febuxostat to the solventranges from 1:5 to 1:20, the Febuxostat is based on gram and the volume of the solvent is based on milliliter; after dissolution, placing the solution in a water bath at 25 to 40 DEG C, standing, stirring for 20 to 40 minutes upon the precipitation of crystals; placing at -15 to 0 DEG C to continue to precipitate crystals for 8 to 10 hours, and filtering; and after filtering, drying at 65 DEG C under vacuum for 6 to 8 hours to obtain the Febuxostat crystal A. The Febuxostat crystal A prepared by the invention is high in purity and yield, the process is simple and easy to implement, the yield is 92.0 to 98.0 percent and the purity is more than 99.90 percent.
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