Curative effects of Tongxinluo(通心络) on patients with ischemic cerebrovascular diseases and without acute stroke

Objective: To explore the curative effects of Tongxinluo(通心络) on patients with ischemic cerebrovascular diseases(ICD) and without acute stroke,and study the characters of the changes of(lysophospholipid).Methods: Two hundred and sixty-six patients with ICD were randomly divided into(treatment) group (n=228) and positive control group(n=38) as the ratio of 1∶6,and 38 healthy adults were selected as normal controls.Patients in treatment group were treated with Tongxinluo capsules(通心络胶囊) 2 pills for 3 times per day,taking 1 hour after meals,combined with aspirin 80 mg for 1530 days consecutively.Patients in positive control group took hydergine 5 mg for 3 times per day,taking 1 hour after meals,combined with aspirin 80 mg for 1530 days consecutively.The clinical symptoms were classified according to the standards of American Stroke Union.Lysophosphatidic acid(LPA) was assayed by colorimetric method.Results: The clinical symptoms of patients with ICD were distributed asymmetrically.The first kind of(symptoms),such as trouble in walking,dizziness,loss of balance and incoordination appeared frequently,(accounting) for more than 60%.Sudden confusion,trouble in speaking or understanding appeared less than(1%).(Tongxinluo) improved clinical symptoms evidently.The plasma LPA levels were elevated in these(patients).The effect of Tongxinluo on reducing LPA levels was time-dose dependent.The effect increased by(prolongation) of the therapeutic time for patients with diabetes,hypertension and hyperlipemia.(Conclusion): (Trouble) in walk and dizziness occurs more frequently in patients with ICD and without acute stroke,and plasm LPA level is significantly elevated.Tongxinluo is effective in treatment of ICD.