High KI67 expression is associated, in a multi-variate model, with lower risk of biochemical recurrence in prostate cancer patients following radical prostatectomy

21112 Background: The prediction of disease progression in prostate cancer patients following radical prostatectomy (RP) remains problematic. The use of molecular markers could offer a better stratification of patients more at risk of progression. As such, we recently reported that nuclear ErbB3 was associated with Gleason score and hormone-refractory status. The objective of this study was to evaluate whether ErbB3 could predict overall biochemical recurrence (BCR). In addition, we evaluated if three nuclear markers known to be associated with progression (Cyclin D1, Ki67 and androgen receptor) were more significant predictors of BCR than ErbB3 alone or in combination. Methods: Using immunohistochemistry, we analyzed a tissue microarray containing 373 cores from 63 RP specimens. No patient had received hormone therapy prior to surgery and prior to BCR. The quantitative analysis of nuclear staining was measured by two independent observers (ErbB3, Cyclin D1 and AR) or with the ImagePro Plus softwareTM (Ki...