MMP-13 selective isonipecotamide alpha-sulfone hydroxamates.

Stephen A. Kolodziej,Susan L. Hockerman,Gary A. DeCrescenzo,Joseph J. McDonald,Debbie A. Mischke,Grace E. Munie,Theresa R. Fletcher,Nathan W. Stehle,Craig Swearingen,Daniel P. Becker

MMP-13 selective isonipecotamide alpha-sulfone hydroxamates.

2010

Stephen A. Kolodziej
Susan L. Hockerman
Gary A. DeCrescenzo
Joseph J. McDonald
Debbie A. Mischke
Grace E. Munie
Theresa R. Fletcher
Nathan W. Stehle
Craig Swearingen
Daniel P. Becker

A series of N-aryl isonipecotamide α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.

Keywords:

Chemical synthesis
Selectivity
Matrix metalloproteinase inhibitor
Organic chemistry
Biological activity
Sulfone
Carboxamide
Stereochemistry
Hydroxamic acid
Enzyme inhibitor
Chemistry
Biochemistry

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