Expression of RUNX3 and EZH2 in endometrial adenocarcinoma tissue

Aim:To investigate the roles and correlation of RUNX3 and EZH2 in pathogenesis and development of endometrial adenocarcinoma.Methods:The expressions of RUNX3 and EZH2 in endometrial adenocarcinomas(60 cases),endometrial hyperplasia(40 cases) and normal endometrium at proliferative phase(20 cases) tissue were detected by immunohistochemical SP method.Results:In endometrial adenocarcinoma,endometrial hyperplasia and normal endometrium,the positive rates of RUNX3 expression were 43.3%(26/60),67.5%(27/40),and 95.0%(19/20),and there were significant differences among the 3 groups(χ2=18.090,P0.001).The positive rates of EZH2 expression were 75.0%(45/60),42.5%(17/40),and 15.0%(3/20),and there were significant differences among the 3 groups(χ2=25.041,P0.001).In endometrial adenocarcinoma tissue,the expression of RUNX3 was related with histological grade,progression of clinical stage and depth of myometrial invasion(χ2=-3.561,-2.367,5.370,P0.05);the expressions of EZH2 was related with histological grade and depth of myometrial invasion(χ2=-3.084,5.568,P0.05);the expressions of RUNX3 and EZH2 were negatively correlated(rP=0.330,P=0.007).Conclusion:RUNX3 inactivation and EZH2 overexpression may play important roles in the carcinogenesis and development of endometrial adenocarcinoma,and the overexpression of EZH2 may be involved in the inactivation of RUNX3 expression.