Technology of large-scale refining production of glycyrrhetate

The invention relates to a technology of large-scale refining production of glycyrrhetate, comprising the following steps: grinding, extracting by water, supercritically extracting CO2, separating, acidizing, crystallizing, decoloring and recrystallizing. The glycyrrhizic acid ion of glycyrrhetate prepared by the technology contains trivalent ions, divalent ions and monatomic ions. The glycyrrhetate comprises metal ions, such as ammonium, potassium, sodium, magnesium, zinc, bismuth and the like; the purity of the glycyrrhetate exceeds 99%. The invention has the advantages of advanced technology, simple operation, ideal refining and high product purity and is convenient for producing on large scale, and raw material conforms to medical application.