TCT-30 PREMIUM Trial: Double blind study of percutaneous closure of patent foramen ovale with the AMPLATZER® PFO Occluder as a treatment for migraine with or without aura

Population studies have identified a correlation between migraine and patent foramen ovale (PFO), and observational studies have reported that PFO closure results in improvement in migraine in some patients. The PREMIUM Trial was a randomized, sham-controlled, double blind study of percutaneous