Single-cell molecular profiling of fluid biopsies of epithelial ovarian cancer

The immediate goal of this project is to identify rare circulating tumor cells (CTC) in the bloodstream of epithelial ovarian cancer (EOC) patients and to apply high content, single cell assays that will yield information on morphology, protein expression and genomic structure. The ultimate goal is to develop a minimally invasive “fluid biopsy” for ovarian patients that can provide detailed information on the patient’s response to therapy, early warnings of potential resistance or relapse, and genetic predictors for the most appropriate therapy.