Efficacy of T-DM1 for leptomeningeal and brain metastases in a HER2 positive metastatic breast cancer patient: new directions for systemic therapy - a case report and literature review

Giuseppina Rosaria Rita Ricciardi,Alessandro Russo,Tindara Franchina,Silvia Schifano,Giampiero Mastroeni,Anna Santacaterina,Vincenzo Adamo

Efficacy of T-DM1 for leptomeningeal and brain metastases in a HER2 positive metastatic breast cancer patient: new directions for systemic therapy - a case report and literature review

2018

Giuseppina Rosaria Rita Ricciardi
Alessandro Russo
Tindara Franchina
Silvia Schifano
Giampiero Mastroeni
Anna Santacaterina
Vincenzo Adamo

Background Herein, we report a complete response after whole brain radiotherapy (WBRT) and concomitant T-DM1 in a patient with HER2-positive metastatic breast cancer (MBC) and extensive brain and leptomeningeal involvement.

Keywords:

Cancer research
Medicine
Whole brain radiotherapy
Surgical oncology
Trastuzumab emtansine
Systemic therapy
Metastatic breast cancer
Prospective cohort study
Pathology
Internal medicine
complete resolution
Oncology
Concomitant

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