A kind of continuous method for preparing Gabapentin

The invention belongs to pharmaceutical chemicals synthesis field, and in particular to a kind of continuous method for preparing Gabapentin.The present invention passes through 1, Hoffmann rearrangement reaction occurs at relatively high temperatures for 1 cyclohexanediacetic acid monoamides, and the isocyanates direct hydrolysis of generation obtains DOPA spray fourth, needs the process of multistep temperature control to be reduced to a step script and continuously prepare, flow is simple, and reaction time is short；Require relatively low for Temperature-controlled appliance；Due to pyroreaction, reaction rate is fast, it is not necessary to add much excessive sodium hypochlorite and sodium hydroxide to improve reaction rate, saves raw material, effectively alleviates subsequent wastewater treatment pressure；Continuous reaction, it is easy to reaction process is monitored and controlled；Two fluids is realized in microreactor rapidly and efficiently to be mixed, and moment reaches homogeneous reaction environment, and reaction efficiency is high, and the amplification of this kind of microreactor is easy.