Mn(III)-Mediated Cascade Cyclization of 1-(Azidomethyl)-2-Isocyanoarenes with Organoboronic acids: Construction of Quinazoline Derivatives

A novel and efficient Mn(III)-mediated oxidative radical cascade reaction of 1-(azidomethyl)-2-isocyanoarenes with organoboronic acids is reported. The single electron oxidation of a commercially available organo boronic acid in the presence of a mild oxidant, Mn(OAc)3·2H2O, resulted in moderate yields of the corresponding quinazoline derivatives.