Chronobiological approach to etiology of urinary stone disease

To study circadian rhythm pattern of biochemical parameters important in etiology of urolithiasis viz. serum calcium, urinary calcium and urinary oxalate in healthy controls in order to set time-quantified norms of their levels in tropical conditions; and to compare with them the rhythm patterns of these parameters in patients of urolithiasis. North and northwestern India being in the stone belt, urolithiasis is a very common problem on our OPD rolls, its etiology being more confusing than conclusive, exploration of an alterative etiological approach to urolithiasis and its recurrence is being sought keeping in mind the time structure of human being.