Id proteins synchronize stemness and anchorage to the niche of neural stem cells
2012
Iavarone, Lasorella and colleagues develop genetic mouse models to study the roles of inhibitor of DNA-binding (Id) proteins in neural stem-cell maintenance. They show that Id proteins promote neural stem-cell adhesion to their niche by driving the transcriptional repression of Rap1GAP, thereby maintaining the activity of the Rap1 GTPase, a known regulator of integrin adhesion.
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