Abstract 16606: 30-day and 2-year Prognostic Information of Total Atheroma Volume, Segment Stenosis Score, and Traditional Coronary Artery Stenosis Assessment by CT Angiography - Results From the CORE320 International Study

Introduction: Among abundant information on coronary artery disease (CAD) features by CT angiography (CTA), total atheroma volume and segment stenosis score (SSS) have recently shown promise for clinical utility. Methods: We followed 379 patients with suspected or known CAD enrolled in the CORE320 study for 2 years after 320-detector row CT coronary angiography. CT images were analyzed for semi-automatically derived total % atheroma volume (total atherosclerotic burden/vessel volume analyzed) and SSS in addition to traditional stenosis assessment (≥50%). Outcome variables were 1) 30-day revascularization and 2) major adverse cardiac events (MACE) after 2 years follow up. Events included cardiac death, myocardial infarction, hospitalization for acute chest pain or heart failure, arrhythmia, and revascularization. Area under the curve (AUC) and Kaplan-Meyer analysis were used to compare risk prediction and survival analysis according to CT CAD characteristics. Results: Thirty-day revascularization was most ...