HIP1 expression and response to chemotherapy in breast cancer.

1046 Background: Huntingtin Interacting Protein 1 (HIP1) is a binding protein to inositol and clathrina that is related to neurodegeneration. Signaling of growth factors receptors trought clathrina is one of the mechanisms by which cells regulate the intracellular signaling. There have been observed high levels of HIP1 protein in breast, colon, kidney, lung, melanoma, ovarian and prostate cancer. Furthermore, HIP expression was negatively correlated with survival in prostate cancer. HIP1 overexpression has been shown to inhibit the degradation of EGFR and estrogen receptor. EGFR expression has been correlated with response to chemotherapy in triple negative breast cancer. Methods: Tumor biopsies were obtained from 83 breast cancer patients (p) treated with neoadjuvant chemotherapy, based on four cycles of fluorouracil, epirubicin and cyclophosphamide. Estrogen receptor, progesterone receptor, HER2, cytokeratin 5/6, vimentin and HIP1 were examined by tissue microarray. HER2 were also assessed by chromogeni...