ADAMTS Gen Ailesinin Obstetrik ve Jinekolojideki Yeri

Matrix metalloproteinases with thrombospondin motifs (A disintegrin-like and Metalloproteinase with Thrombospondin type-1 motif, ADAMTS) firstly described as inflammation-related genes in colon carcinoma by Japanese researchers have a large gene family with the current 19 members. These proteinases which are secreted into extracellular matrix have important roles in matrix formation and degradation, remodeling, coagulation, fibrosis and in many other physiological processes. These enzymes are critical in many pathological situations such as cancers, musculoskeletal disorders and autoimmune events. Recent studies about these proteinases showed their importance in the reproductive system as well. The goal of this review is to provide basic information about the roles of ADAMTS enzymes in the pathophysiology of reproductive system diseases to the researchers of obstetric and gynecology field and to open new insights about this subject.