Role of Liver on Consequences of Lipid Mobilization.

Summary(1) The role of the liver on the consequences of lipid mobilization from the depots by LM was investigated in sensitized and desensitized rats. (2) Sensitization to the hyperlipemic action of LM involved administration of minute amounts of potential hepatotoxic agents which produced “subclinical” fatty liver as determined by chemical analysis. (3) Desensitization to the hyperlipemic action of LM occurred when the potential hepatotoxic agents were removed from the diet. (4) The liver in desensitized or fed sensitized rats was capable of handling the mobilized lipid without consequent hyperlipemia. (5) Fasted, sensitized rats were not capable of handling the fat load and hyperlipemia resulted. (6) The source of the cholesterol and lipid P in the hyperlipemic rats was the liver. (7) LM actively and immediately mobilized triglycerides from the depots and this action did not depend upon sensitization or fasting.