A three-dimensional computational model of action potential propagation through a network of individual cells

It has been suggested in the literature that a disorganisation of cardiac tissue at the cellular scale may affect the propagation of the action potential (AP) at the tissue scale, and may play a role in arrhythmia. We developed a model of the myocardium at sub-cellular resolution in which the intracellular space, the cell membrane, and the extracellular space are discretized individually. We tested this approach on small, hand-crafted two- and three-dimensional networks of cells.