Divergent Effects of Raloxifene HCl on the the Pharmacokinetics and Pharmacodynamics of Warfarin

Purpose. Evista® (raloxifene HCl) is a nonsteroidal selective estrogen receptor modulator that displays estrogen agonist effects on bone and lipid metabolism but estrogen antagonist effects on the breast and endometrium. The potential for drug-drug interaction between raloxifene and warfarin was assessed in 15 healthy postmenopausal women.