Fibrin-filaggrin chimeric polypeptide citruinado capable of detecting the antibodies generated in rheumatoid arthritis.

Filaggrin chimeric polypeptide fibrin-citrullinated capable of detecting the antibodies generated in rheumatoid arthritis. The present invention relates to a chimeric polypeptide, capable of detecting the antibodies generated in rheumatoid arthritis, comprising at least two peptide subunits citrullinated: (i) from the string \ alpha or \ beta fibrin and (ii) a second from filaggrin. Furthermore, the invention comprises an antigenic composition, a method and kit for the diagnosis of rheumatoid arthritis, from the detection of the autoantibodies generated during the course of the disease.