[The discussion of the correlation between tumor necrosis factor-alpha and aquaporin 4 expression in critical poisoning brain edema].

Critical poisoning is a critical illness. Cerebral edema after poisoning is one of the important factors that cause the patient's condition to worsen and affect the prognosis of patients after acute brain injury. Aquaporin 4 (AQP-4) is an important member of the aquaporin family and is abundantly expressed in the central nervous system, playing a pivotal role in the formation of cerebral edema. Brain injury can cause the secretion of inflammatory transmitters, causing or aggravating cerebral edema. Tumor necrosis factor-alpha (TNF-α) has been confirmed to be most closely related to cerebral edema, and can participate in the formation and development of brain edema by regulating AQP-4.