Prevalence of metabolic syndrome and population attributable risk for cardiovascular, stroke, and coronary heart diseases as well as myocardial infarction and all-cause mortality in middle-east: Systematic review & meta-analysis

Abstract Metabolic syndrome (MS) is a cluster of risk factors which associated with cardiovascular disease, myocardial infraction, stroke, and mortality due to these diseases. There is not a clear and comprehensive dataset of the MS prevalence in middle-east countries whilst the frequency of disease is increasing in both developed and developing countries. Then, the present study aimed to estimate the prevalence of the metabolic syndrome among all 15 countries located in middle-east region. A meta-analysis was conducted on a total of 61 eligible studies with a total of 120071 individuals which were selected and critically appraised through a systematic approach within each country. The pooled estimates of MS varied in different areas with a range of 23.6% in Kuwait to 40.1% in U.A Emirates. Overall, nearly one-third of population (around 80,000,000) suffering from MS in the Middle-East. Moreover, the west countries in this area have relatively higher prevalence than those located in the east. The highest Population Attributable Risk (PAR) of the diseases due to MS was related to the mortality because of cardiovascular disease (29.6 per cent) compared to the lowest one was obtained for coronary heart disease (17.2 per cent). The study also verified PAR for stroke, myocardial infraction, and all-cause mortality overall and by country. Present findings strongly support the fact that high prevalence of MS have notifiable portion in developing cardiovascular disease, stroke, myocardial infarction and mortality. Therefore, it should be regarded as a major health concern in the region.