THU0372 NEUROPATHIC PAIN IN THE PATIENTS WITH SPONDYLOARTHRITIS: RELATINSHIP WITH FATIGUE, SLEEP QUALITY AND QUALITY OF LIFE

Background Neuropathic pain is defined as the pain that arises as a direct consequence of a lesion or diseases affecting the somatosensory system. Low back pain has nociceptive, neuropathic or mixed components. Inflammatory back pain is one of the key clinical criteria for the classification of spondyloarthritis (SpA). There are no accurate data for the overall prevalence of neuropathic pain in the inflammatory disorders. Objectives In the present study we aimed to determine whether there is a neuropathic component in SpA and also to determine the relationship with disease activity, clinical findings, fatigue, sleep quality and quality of life. Methods Eighty SpA patients fulfilling the Assessment of SpondyloArthritis International Society (ASAS) classification criteria for SpA (M/F=42/38) (37.3±11 years), 53 patients with chronic low back pain (CLBP) (M/F=22/31) (45.5±13.6 years) and 50 healthy controls (M/F =28/22) (38.1 ±12.7years) were enrolled in the study. Pain was assessed with visual analogue scale (VAS rest and activity), disease activity with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), functional capacity with Bath Ankylosing Spondylitis Functional Index (BASFI), fatigue with multidimensional assessment of fatigue (MAF), sleep quality with Pittsburgh Sleep Quality Index (PSQI) and quality of life was assessed with Short Form 36 (SF-36). Neuropathic pain was determined by using painDETECT questionnaire, a simple and reliable screening questionnaire. Scores ≤12 indicate that a neuropathic pain component is unlikely, and scores ≥19 indicate that neuropathic component is very likely to be present. Scores between 12 and 19 suggest that the result is unclear. Results The PainDETECT score of the SpA patients, CLBP patients and healthy controls were 12.06±5.9, 13.8±7.5, 2.6±4.2, respectively. While there was no significant difference between the patients with SpA and CLBP (p>0.05), the SpA patients had significantly higher scores than the healthy controls (p Conclusion We found that SpA and CLBP patients had higher painDETECT scores than the healthy controls. 17% of the SpA patients had neuropathic pain. We also found that neuropathic pain was correlated with fatigue, sleep quality and quality of life. Since pain in SpA consists of inflammatory and neuropathic components, a better understanding of neuropathic pain mechanisms in SpA will provide a more targeted approach to the assessment and treatment of patients. References [1] Bidad K, Gracey E, Hemington KS, et al. Pain in ankylosing spondylitis: a neuro-immune collaboration. Nat Rev Rheumatol. 2017;13(7):410-420 [2] Bennett MI, Attal N, Backonja MM, et al. Using screening tools to identify neuropathic pain. Pain2007;127(3):199-203 [3] Wu Q, Inman RD, Davis KD. Neuropathic pain in ankylosing spondylitis: a psychophysics and brain imaging study. Arthritis Rheum. 2013;65(6):1494-503 Disclosure of Interests None declared