Loperamide hydrochloride-casein composite nanoparticles, as well as preparation method and application thereof

The invention relates to loperamide hydrochloride-casein composite nanoparticles, as well as a preparation method and application thereof, and particularly discloses loperamide hydrochloride-casein composite nanoparticles, wherein loperamide hydrochloride is dispersed into nano-carriers formed by casein in an amorphous form. The preparation method comprises the following steps: 1) preparing a casein solution; 2) preparing a loperamide hydrochloride solution; 3) adding the loperamide hydrochloride solution obtained in the step 2) into the casein solution; 4) adjusting the pH value of the solution obtained in the steps 3) to be 5.5 to 8.5; 5) performing ultrasonic dispersion on the solution obtained in the step 4) to obtain the loperamide hydrochloride-casein composite nanoparticles. The loperamide hydrochloride-casein composite nanoparticles has the effects of improving the solubility of the loperamide hydrochloride, covering up the bitter taste of the loperamide hydrochloride, selectively releasing in gastric juice and improving the bioavailability, so as to achieve higher compliance and achieve the curative effect of treating gastrointestinal inflammation and dysentery.