Epigenetic Regulation of Vascular Smooth Muscle Cells by Histone H3 Lysine 9 Dimethylation Attenuates Target Gene-Induction by Inflammatory Signaling

Jennifer L. Harman,Lina Dobnikar,Joel Chappell,Benjamin G. Stokell,Amanda Dalby,Kirsty Foote,Alison Finigan,Paula Freire-Pritchett,Annabel L. Taylor,Matthew D. Worssam,Ralitsa R. Madsen,Elena Loche,Anna K. Uryga,Martin R. Bennett,Helle F. Jørgensen

Epigenetic Regulation of Vascular Smooth Muscle Cells by Histone H3 Lysine 9 Dimethylation Attenuates Target Gene-Induction by Inflammatory Signaling

2019

Jennifer L. Harman
Lina Dobnikar
Joel Chappell
Benjamin G. Stokell
Amanda Dalby
Kirsty Foote
Alison Finigan
Paula Freire-Pritchett
Annabel L. Taylor
Matthew D. Worssam
Ralitsa R. Madsen
Elena Loche
Anna K. Uryga
Martin R. Bennett
Helle F. Jørgensen

Objective: Vascular inflammation underlies cardiovascular disease. Vascular smooth muscle cells (VSMCs) upregulate selective genes, including MMPs (matrix metalloproteinases) and proinflammatory cy...

Keywords:

Vascular smooth muscle
Proinflammatory cytokine
Epigenetics
Inflammation
Chromatin immunoprecipitation
Cell biology
Biochemistry
Histone H3
Biology
Matrix metalloproteinase
Histone
Myocyte

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