EFFECTS OF COMPOUND EARTHWORM CAPSULE ON AIRWAY INFLAMMATION AND IL-23 IN SERUM OF ASTHMA MICE

Objective:To observe the effects of Compound earthworm capsule on airway inflammation and IL-23 level in serum of asthma mice.Methods:50 mice were randomly divided into 5 groups(n=10): control group,asthma model group,Compound earthworm capsule high dose group,Compound earthworm capsule low dose group and dexamethasone group.The asthma mice model was made by peritoneal injection of ovalbumin and motivated by atomization inhalation.HE stain was used to observe the morphology of lungs of mice in each group,ELISA to detect IL-23 level in serum.Results:The general conditions of mice in each treatment group were obviously better than model mice.Compared with model mice,the pathological changes of lung tissue of mice in Compound earthworm capsule treatment group and dexamethasone group alleviated markedly.The IL-23 level in serum of mice in Compound earthworm capsule treatment group and dexamethasone group were obviously lower than that of mice in model group(P 0.01).Conclusions:Compound earthworm capsule can inhibit airway inflammation of asthma mice signif icantly;and also can regulate immune system by decreasing IL-23 level in serum;moreover,the effects of Compound earthworm capsule are similar with dexamethasone.