Research progress on role of ferroptosis suppressor protein 1 in human diseases

Ferroptosis suppressor protein 1 (FSP1), confirmed as a ferroptosis-resistant factor recently, plays a key role in the oncogenesis and progress of human diseases, such as breast cancer, ovarian cancer, lung cancer, hepatocellular carcinoma, melanoma, lymphoma, leukemia, copper resistance, severe acute pancreatitis, and diabetes. FSP1 is regarded as a double-edged sword according to previous studies. Mechanically, FSP1 triggers caspase-independent apoptosis via its C-terminal fragments, nuclear translocation, or over-expression, and inhibits ferroptosis through FSP1-CoQ10-NAD(P)H axis, being independent of the glutathione (GSH)-GPX4 axis. The research progress in action mechanism of FSP1 in human diseases is briefly described in this review for providing novel preventative and therapeutic target molecules for human diseases. DOI: 10.11855/j.issn.0577-7402.2021.07.14