Development of UV spectroscopic method for the estimation of s(-) Amlodipine andHydrochlorothiazide in dosage forms by simultaneous equation method

S(-) amlodipine is a potent calcium channel blocker used for the treatment of hypertension, congestive heart failure and angina pectoris. S(-) amlodipine avoids the adverse effect of amlodipine in racemic mixtures. Hydrochlorothiazide is a first line diuretic drug of the thiazide class used for the treatment of hypertension, congestive heart failure and symptomatic edema. Literature review indicated that, various methods have been reported for the analysis of S(-) amlodipine and hydrochlorothiazide in formulation by RP-HPLC, HPTLC. But no analytical methods were reported for the estimation of these drugs using UV spectroscopic by simultaneous equation method.