Preparation and biodistribution of 131 I-labeled graphene quantum dots

For the superiority of graphene quantum dots (GQDs) in bioimaging and drug delivery carrier, GQDs bring new opportunities for theranostics of diseases. In this study, GQDs were successfully prepared and labeled with 131I. The in vitro properties, biodistribution and SPECT imaging of 131I-GQDs were investigated. The uptake of 131I-GQDs at tumor sites can be clearly observed via SPECT imaging and T/B and T/M ratios increase with increasing time, which can contribute to enhanced permeability and retention (EPR) effect.