Transdermal Scopolamine in the Treatment of Vertiginous Episodes Associated with Ménière’s Disease

The parasympatholytic drugs, the antihistamines, and the phenothiazine tranquilizers all have a central depressant action and have long been used in preventing or treating motion sickness. The most widely used drugs are those with few atropine-like or sedative side-effects and thanks to the interest of the armed forces, many field studies and clinical trials evaluating drugs against motion sickness are available [1, 2]. In 1966, Brand and Perry [3] compiled exhaustive reviews on drugs used in motion sickness. They reported that there is no substitute for l-hyoscine (scopolamine) where the aim is to provide quick action but short-term protection against exposure to severe motion, but that for the prophylaxis of motion sickness during a long voyage, the diphenhydramine, cyclizine, may afford adequate protection.