A Study on Role of Circulating Hscrp As A Biomarker of Clinical Significance in Acute Mi And Identification of Extent of Involvement, Risk Assessment And Post Mi Complications.

Introduction: Myocardial infarction (MI) due to coronary artery disease (CAD) has become a leading cause of death worldwidesurpassing malnutritionandinfectiousdiseasesespecially ina developingcountrylikeIndia. However, recent technological advances in diagnostic tools have led to the utilization of various blood biomarkers of clinical significance in detecting heart disease like myocardial infarction at an early stage. Various lipid, protein and enzymatic biomarkers like lipoproteins, CK-MB, troponin and inflammatory acute phase proteins have been studied extensively for the early detection and management. There is a need for studies involving a single biomarker of detection as well as for identification of the extension of involvement to decide on effective management of patient. Hence we have focused on the study of variations in serum high sensitive C reactive protein (hsCRP) concentration and its correlation with the extent of lesion involvement in MI. Some clinicalstudies have showncirculatinglevelsofCRPcorrelatingwithtotalinfarctsizeinacute MI, post MI complications andwithprognosis. ThusCRPisbeginning to emerge as a markerofunderlyingcoronaryinflammationindicating the extentofmyocardial necrosis. Keeping in view the significance of this aspect of role of hsCRP estimation, we studied 50 cases presenting with acute coronary syndrome (ACS) to King George Hospital, Visakhapatnam,India from December 2012 to September 2014. We measured hsCRP level in each patient to determine the association between hsCRP and ACS and its significance in the prognosis.