Phosphocreatine immobilization of the surface of silica and magnetite nanoparticles for targeted drug delivery
2019
A method is proposed for immobilization of anti-ischemic drug phosphocreatine on the surface of aminated silica and magnetite nanoparticles of similar size and shape. The synthesis of spacer and the coordination-ionic drug immobilization technique are described. Magnetite nanoparticles demonstrated much more efficient chemisorption of phosphocreatine than silica nanoparticles. The method was recommended for practical application.
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