ASSA13-15-9 A Meta-Analysis of Percutaneous Coronary Intervention For Chronic Total Coronary Occlusions Recanalization

Background Despite advances in procedural techniques and expertise, PCI for CTO recanalization in select patients remains a challenge. Objective To perform an evaluation (meta-analysis) on short-term and long-term prognosis of percutaneous coronary intervention (PCI) for patients with chronic total occlusions (CTO) recanalization. Methods Data sources included published studies from a search of PUBMED, ELSEVIER, and CLINICAL.COM from January 2000 to July 2012. Selected studies were either observational studies or randomised clinical trials that compared PCI treatment of CTO recanalization to medical management. The endpoints were analysed using pooled estimates for death, myocardial infarction (MI), coronary artery bypass surgery (CABG), angina symptoms, repeat revascularization, and major adverse cardiac events (MACE). Results Sixteen observational studies comparing outcomes after failed or successful CTO recanalization with PCI were included in the current analysis. Collectively, these studies enrolled 10,256 patients who were observed at an average follow-up period of 5 years. Patients with successful CTO recanalization demonstrated significantly reduced rates of all-cause death (P Conclusions PCI should be considered an effective option for the patients with CTO lesions.