Using Gelatin Nanoparticle Mediated Intranasal Delivery of Neuropeptide Substance P to Enhance Neuro-Recovery in Hemiparkinsonian Rats

Ying-Zheng Zhao,Rong-Rong Jin,Wei Yang,Qi Xiang,Wen-Ze Yu,Qian Lin,Fu-Rong Tian,Kai-Li Mao,Chuan-Zhu Lv,Yi-Xiang J. Wang,Cui-Tao Lu

Using Gelatin Nanoparticle Mediated Intranasal Delivery of Neuropeptide Substance P to Enhance Neuro-Recovery in Hemiparkinsonian Rats

2016

Ying-Zheng Zhao
Rong-Rong Jin
Wei Yang
Qi Xiang
Wen-Ze Yu
Qian Lin
Fu-Rong Tian
Kai-Li Mao
Chuan-Zhu Lv
Yi-Xiang J. Wang
Cui-Tao Lu

Purpose Intranasal administration of phospholipid-based gelatin nanoparticles (GNP) was prepared to investigate the neuro-recovery effects of neuropeptide Substance P (SP) on hemiparkinsonian rats.

Keywords:

Phospholipid
Nasal administration
Oxidopamine
Dopamine
Apoptosis
Substance P
Pharmacology
Gelatin
Medicine
Neuropeptide

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