Diversity-oriented synthesis of N,N-dimethylamino-substituted azoles employing TBTU

Abstract A convenient, diversity-oriented approach for the transformation of readily available amidoximes, o -hydroxyarylamines, acyl hydrazines, carboximidohydrazides and thiohydrazides into their respective N,N -dimethylamino-substituted azoles is described. The method is particularly suitable for array chemistry application as it employs a stable, solid reagent TBTU.