Нейротрофический фактор головного мозга: структура и взаимодействие с рецепторами

This scientific review, pursuing the objective of investigating the structure of the brain-derived neurotrophic hormone, as well as the interaction of its isoforms with the main TrkB and p75NTR receptors, submits the analysis of Russian and foreign publications, pertaining to this topic. We also pay attention to the main mechanisms of signaling pathways activation in the course of the interaction between proteins and receptors. We describe the possible role of TrkB and p75NTR in the pathogenesis of depression, looking at the possible influence of the misbalance of these receptors on the development of this disorder. This determines the novelty of this work and the strategy for further investigation of the mechanisms of interconnection between the brain-derived neurotrophic factor and depression. We had analyzed over 200 sources, 40 of which have been included into the review.